nf-core/drugresponseeval
Pipeline for testing drug response prediction models in a statistically and biologically sound way.
Define the models and baselines to be tested.
Model to be tested.
stringModel to be tested.
Baselines to be tested.
stringBaselines to be tested.
Define where the pipeline should find input data and save output data.
Run ID for the pipeline.
stringYou will need to set a run identifier for the pipeline. This is used to create a unique output directory for each run.
Name of the dataset.
stringName of the dataset used for the pipeline. This can be either one of the provided datasets ('GDSC1', 'GDSC2', 'CCLE', 'CTRPv2', 'Toy_Data') in which case the datasets with the fitted curves is downloaded, or a custom dataset name, pointing either to raw viability measurements for automatic curve fitting (see 'curve_curator' option, which is required in this case), or prefit data (not recommended for dataset comparability reasons due to potential differences in fitting procedures).
The output directory where the results will be saved. Default is results/
stringEmail address for completion summary.
string^([a-zA-Z0-9_\-\.]+)@([a-zA-Z0-9_\-\.]+)\.([a-zA-Z]{2,5})$Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits. If set in your user config file (~/.nextflow/config) then you don't need to specify this on the command line for every run.
Define the mode in which the pipeline will be run.
Run the pipeline in test mode LPO (Leave-random-Pairs-Out), LCO (Leave-Cell-line-Out), or LDO (Leave-Drug-Out).
stringLPOWhich tests to run (LPO=Leave-random-Pairs-Out, LCO=Leave-Cell-line-Out, LDO=Leave-Drug-Out). Can be a list of test runs e.g. 'LPO LCO LDO' to run all tests. Default is LPO.
Options for randomization.
Randomization mode for the pipeline.
stringWhich randomization tests to run, additionally to the normal run. Default is None which means no randomization tests are run. Modes: SVCC, SVRC, SVCD, SVRD. Can be a list of randomization tests e.g. 'SCVC SCVD' to run two tests. Default is None. SVCC: Single View Constant for Cell Lines: in this mode, one experiment is done for every cell line view the model uses (e.g. gene expression, mutation, ..). For each experiment one cell line view is held constant while the others are randomized. SVRC Single View Random for Cell Lines: in this mode, one experiment is done for every cell line view the model uses (e.g. gene expression, mutation, ..).
Randomization type for the pipeline.
stringpermutationtype of randomization to use. Choose from "permutation", "invariant". Default is "permutation
Options for robustness.
Number of trials to run for the robustness test
integerNumber of trials to run for the robustness test. Default is 0, which means no robustness test is run. The robustness test is a test where the model is trained with varying seeds. This is done multiple times to see how stable the model is.
Options for data input.
Path to the data directory.
stringPath to the data directory.
The name of the measure to use
stringLN_IC50Datasets for cross-study prediction.
stringList of datasets to use to evaluate predictions across studies. Default is empty string which means no cross-study datasets are used.
Additional options for the pipeline.
If True, use refit measures instead of original measures reported by the authors for the available datasets, or invoke automatic fitting of custom raw viability data.
booleanThis allows using refit measures (see 'measure' option for details) for available datasets, which allows better comparability between datasets. When providing a custom dataset (see 'dataset_name' option), setting this to True expects a csv-formatted file at <path_data>/<dataset_name>/<dataset_name>_raw.csv (also see 'path_data' option), which is fitted automatically with the same procedure as the available datasets, to provide fair comparison. The fitted data will then be stored at <path_data>/<dataset_name>/<dataset_name>.csv.
Optimization metric for the pipeline.
stringRMSEOptimization metric for the pipeline. Default is RMSE.
Number of cross-validation splits.
integer10Number of cross-validation splits. Default is 5.
Response transformation
stringTransformation to apply to the response variable possible values: standard, minmax, robust
Model checkpoint directory
stringTEMPORARYDirectory to save model checkpoints.
Parameters used to describe centralised config profiles. These should not be edited.
Git commit id for Institutional configs.
stringmasterBase directory for Institutional configs.
stringhttps://raw.githubusercontent.com/nf-core/configs/masterIf you're running offline, Nextflow will not be able to fetch the institutional config files from the internet. If you don't need them, then this is not a problem. If you do need them, you should download the files from the repo and tell Nextflow where to find them with this parameter.
Institutional config name.
stringInstitutional config description.
stringInstitutional config contact information.
stringInstitutional config URL link.
stringLess common options for the pipeline, typically set in a config file.
Display version and exit.
booleanMethod used to save pipeline results to output directory.
stringThe Nextflow publishDir option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See Nextflow docs for details.
Email address for completion summary, only when pipeline fails.
string^([a-zA-Z0-9_\-\.]+)@([a-zA-Z0-9_\-\.]+)\.([a-zA-Z]{2,5})$An email address to send a summary email to when the pipeline is completed - ONLY sent if the pipeline does not exit successfully.
Send plain-text email instead of HTML.
booleanDo not use coloured log outputs.
booleanIncoming hook URL for messaging service
stringIncoming hook URL for messaging service. Currently, MS Teams and Slack are supported.
Boolean whether to validate parameters against the schema at runtime
booleantrueBase URL or local path to location of pipeline test dataset files
stringhttps://raw.githubusercontent.com/nf-core/test-datasets/Suffix to add to the trace report filename. Default is the date and time in the format yyyy-MM-dd_HH-mm-ss.
string